Validation of the 1,4-butanediol thermoplastic polyurethane as a novel material for 3D bioprinting applications.

ABSTRACT: Tissue engineering (TE) seeks to fabricate implants that mimic the mechanical strength, structure, and composition of native tissues. Cartilage TE requires the development of functional personalized implants with cartilage-like mechanical properties capable of sustaining high load-bearing environments to integrate into the surrounding tissue of the cartilage defect. In this study, we evaluated the novel 1,4-butanediol thermoplastic polyurethane elastomer (b-TPUe) derivative filament as a 3D bioprinting material with application in cartilage TE. The mechanical behavior of b-TPUe in terms of friction and elasticity were examined and compared with human articular cartilage, PCL, and PLA. Moreover, infrapatellar fat pad-derived human mesenchymal stem cells (MSCs) were bioprinted together with

SUBMITTER: Chocarro-Wrona C 

PROVIDER: S-EPMC7823129 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature