Brown Fat-Activating Lipokine 12,13-diHOME in Human Milk Is Associated With Infant Adiposity.

ABSTRACT:

Context

Little is known about the specific breastmilk components responsible for protective effects on infant obesity. Whether 12,13-dihydroxy-9Z-octadecenoic acid (12,13-diHOME), an oxidized linoleic acid metabolite and activator of brown fat metabolism, is present in human milk, or linked to infant adiposity, is unknown.

Objective

To examine associations between concentrations of 12,13-diHOME in human milk and infant adiposity.

Design

Prospective cohort study from 2015 to 2019, following participants from birth to 6 months of age.

Setting

Academic medical centers.

Participants

Volunteer sample of 58 exclusively breastfeeding mother-infant pairs; exclusion criteria included smoking, gestational diabetes, and health conditions with the potential to influ

SUBMITTER: Wolfs D 

PROVIDER: S-EPMC7823229 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature