Relationship of IGF-1 and IGF-Binding Proteins to Disease Severity and Glycemia in Nonalcoholic Fatty Liver Disease.

ABSTRACT:

Context

Growth hormone (GH) and IGF-1 help regulate hepatic glucose and lipid metabolism, and reductions in these hormones may contribute to development of nonalcoholic fatty liver disease (NAFLD).

Objective

To assess relationships between hepatic expression of IGF1 and IGF-binding proteins (IGFBPs) and measures of glycemia and liver disease in adults with NAFLD. Secondarily to assess effects of GH-releasing hormone (GHRH) on circulating IGFBPs.

Design

Analysis of data from a randomized clinical trial of GHRH.

Setting

Two US academic medical centers.

Participants

Participants were 61 men and women 18 to 70 years of age with HIV-infection, ≥5% hepatic fat fraction, including 39 with RNA-Seq data from liver biopsy.

Main outcome measures

Hepatic stea

SUBMITTER: Stanley TL 

PROVIDER: S-EPMC7823253 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature