Bone Mineral Density and Turnover After Sleeve Gastrectomy and Gastric Bypass: A Randomized Controlled Trial (Oseberg).

ABSTRACT:

Context

Bariatric surgery, particularly Roux-en-Y gastric bypass (RYGB), is associated with an increased risk of osteoporotic fractures. It is unknown whether RYGB or sleeve gastrectomy (SG) have different effects on bone health.

Objective

To compare changes in bone mineral density and markers of bone turnover 1 year after SG and RYGB.

Design, setting, patients, and interventions

Randomized, triple-blind, single-center trial at a tertiary care center in Norway. The primary outcome was diabetes remission. Patients with severe obesity and type 2 diabetes were randomized and allocated (1:1) to SG or RYGB.

Main outcome measures

Changes in areal bone mineral density (aBMD) and bone turnover markers.

Results

Femoral neck, total hip, and lumbar spine aBMD, but

SUBMITTER: Hofso D 

PROVIDER: S-EPMC7823313 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature