Causal Relationship between Adiponectin and Diabetic Retinopathy: A Mendelian Randomization Study in an Asian Population.

ABSTRACT: Adiponectin (APN) is suggested to be a potential biomarker for predicting diabetic retinopathy (DR) risk, but the association between APN and DR has been inconsistent in observational studies. We used a Mendelian randomization (MR) analysis to evaluate if circulating APN levels result in DR. We applied three different genetic risk scores (GRS): GRS_All combined all 47 single nucleotide polymorphisms (SNPs), which from a genome-wide association study (GWAS) database-catalog reach significance level; GRS_Limited comprised 16 GRS_All-SNPs with a rigorous threshold (p < 5.0 × 10^-8 for GWAS), and GRS_APN combined 5 SNPs significantly associated with APN level. The MR-inverse-variance weighted method analysis showed that for each 1-SD inc

SUBMITTER: Huang YC 

PROVIDER: S-EPMC7823606 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature