Development of a Safe and Highly Efficient Inactivated Vaccine Candidate against Lumpy Skin Disease Virus.

ABSTRACT: Capripox virus (CaPV)-induced diseases (lumpy skin disease, sheeppox, goatpox) are described as the most serious pox diseases of livestock animals, and therefore are listed as notifiable diseases under guidelines of the World Organisation for Animal Health (OIE). Until now, only live-attenuated vaccines are commercially available for the control of CaPV. Due to numerous potential problems after vaccination (e.g., loss of the disease-free status of the respective country, the possibility of vaccine virus shedding and transmission as well as the risk of recombination with field strains during natural outbreaks), the use of these vaccines must be considered carefully and is not recommended in CaPV-free countries. Therefore, innocuous and efficacious inactivated vaccines against CaPV would pro

SUBMITTER: Wolff J 

PROVIDER: S-EPMC7823700 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature