Complete Genome Sequence of Ovine <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> Strain JIII-386 (MAP-S/type III) and Its Comparison to MAP-S/type I, MAP-C, and <i>M. avium</i> Complex Genomes.

ABSTRACT: Mycobacterium avium (M. a.) subsp. paratuberculosis (MAP) is a worldwide-distributed obligate pathogen in ruminants causing Johne's disease. Due to a lack of complete subtype III genome sequences, there is not yet conclusive information about genetic differences between strains of cattle (MAP-C, type II) and sheep (MAP-S) type, and especially between MAP-S subtypes I, and III. Here we present the complete, circular genome of MAP-S/type III strain JIII-386 (DE) closed by Nanopore-technology and its comparison with MAP-S/type I closed genome of strain Telford (AUS), MAP-S/type III draft genome of strain S397 (U.S.), twelve closed MAP-C strains, and eight closed M.-a.-complex-strains. Structural comparative alignments revealed clearly the mosaic nature of MAP, emph

SUBMITTER: Wibberg D 

PROVIDER: S-EPMC7823733 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature