Zinc Supplementation Modulates NETs Release and Neutrophils' Degranulation.

ABSTRACT: Zinc plays an important physiological role in the entire body, especially in the immune system. It is one of the most abundant microelements in our organism and an essential component of enzymes and antibacterial proteins. Zinc levels were reported to be correlated with the intensity of innate immunity responses, especially those triggered by neutrophils. However, as the results are fragmentary, the phenomenon is still not fully understood and requires further research. In this study, we aimed to perform a comprehensive assessment and study the impact of zinc on several basic neutrophils' functions in various experimental setups. Human and murine neutrophils were preincubated in vitro with zinc, and then phagocytosis, oxidative burst, degranulation and release of neutrophil extracellular t

SUBMITTER: Kuzmicka W 

PROVIDER: S-EPMC7823768 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature