Regulation of Serum Exosomal MicroRNAs in Mice Infected with Orientia tsutsugamushi.

ABSTRACT: Exosomes are small extracellular vesicles that carry proteins, lipids, and nucleic acids. They are circulated in many body fluids and play an important role in intercellular communications. MicroRNAs (miRNAs), as major components of exosomes, are often regulated in many diseases including bacterial and viral infections. Functionally, exosome-carried miRNAs interact with various immune cells and affect their behavior. Little is known whether exosomal miRNAs are regulated during scrub typhus, a potentially lethal infection caused by intracellular bacteria, Orientiatsutsugamushi. In the present study, we utilized a scrub typhus mouse model and collected serum at various time points post infection. A custom quantitative PCR array covering 92 murine miRNAs was used to profile serum exosomal miR

SUBMITTER: Jiang L 

PROVIDER: S-EPMC7823836 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature