Novel Molecular Markers Linked to Pseudomonas aeruginosa Epidemic High-Risk Clones.

ABSTRACT: The population structure of Pseudomonas aeruginosa is panmictic-epidemic in nature, with the prevalence of some high-risk clones. These clones are often linked to virulence, antibiotic resistance, and more morbidity. The clonal success of these lineages has been linked to acquisition and spread of mobile genetic elements. The main aim of the study was to explore other molecular markers that explain their global success. A comprehensive set of 528 completely sequenced P. aeruginosa genomes was analyzed. The population structure was examined using Multilocus Sequence Typing (MLST). Strain relationships analysis and diversity analysis were performed using the geoBURST Full Minimum Spanning Tree (MST) algorithm and hierarchical clustering. A phylogenetic tree was constructed using the Unweight

SUBMITTER: Nageeb W 

PROVIDER: S-EPMC7824207 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature