Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders.

ABSTRACT: The number of patients with central nervous system disorders is increasing. Despite diligent laboratory and clinical research over the past 30 years, most pharmacologic options for the prevention and long-term treatment of central nervous system disorders and neurodegenerative disorders have been unsuccessful. Therefore, the development of drugs and/or functional foods to prevent the onset of neurodegenerative disorders is highly expected. Several reports have shown that polymethoxylated flavones (PMFs) derived from citrus fruit, such as nobiletin, tangeretin, and 3,3',4',5,6,7,8-heptamethoxyflavone, are promising molecules for the prevention of neurodegenerative and neurological disorders. In various animal models, PMFs have been shown to have a neuroprotective effect and improve cognitiv

SUBMITTER: Matsuzaki K 

PROVIDER: S-EPMC7824236 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature