Development of Anti-Virulence Therapeutics against Mono-ADP-Ribosyltransferase Toxins.

ABSTRACT: Mono-ADP-ribosyltransferase toxins are often key virulence factors produced by pathogenic bacteria as tools to compromise the target host cell. These toxins are enzymes that use host cellular NAD+ as the substrate to modify a critical macromolecule target in the host cell machinery. This post-translational modification of the target macromolecule (usually protein or DNA) acts like a switch to turn the target activity on or off resulting in impairment of a critical process or pathway in the host. One approach to stymie bacterial pathogens is to curtail the toxic action of these factors by designing small molecules that bind tightly to the enzyme active site and prevent catalytic function. The inactivation of these toxins/enzymes is targeted for the site of action within the host cell and sm

SUBMITTER: Lugo MR 

PROVIDER: S-EPMC7824265 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature