One4Two^®: An Integrated Molecular Approach to Optimize Infertile Couples' Journey.

ABSTRACT: The current diagnostic path of infertile couples is long lasting and often ineffective. Genetic tests, in particular, appear as a limiting step due to their jeopardized use on one side, and to the limited number of genes evaluated on the other. In this context, the development and diffusion, also in routine diagnostic settings, of next generation sequencing (NGS)-based methods for the analyses of several genes in multiple subjects at a time is improving the diagnostic sensitivity of molecular analyses. Thus, we developed One4Two^®, a custom NGS panel to optimize the diagnostic journey of infertile couples. The panel validation was carried out in three steps analyzing a total of 83 subjects. Interestingly, all the previously identified variants were confirmed, assessing the analyt

SUBMITTER: D'Argenio V 

PROVIDER: S-EPMC7824287 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature