From Prevention to Disease Perturbations: A Multi-Omic Assessment of Exercise and Myocardial Infarctions.

ABSTRACT: While a molecular assessment of the perturbations and injury arising from diseases is essential in their diagnosis and treatment, understanding changes due to preventative strategies is also imperative. Currently, complex diseases such as cardiovascular disease (CVD), the leading cause of death worldwide, suffer from a limited understanding of how the molecular mechanisms taking place following preventive measures (e.g., exercise) differ from changes occurring due to the injuries caused from the disease (e.g., myocardial infarction (MI)). Therefore, this manuscript assesses lipidomic changes before and one hour after exercise treadmill testing (ETT) and before and one hour after a planned myocardial infarction (PMI) in two separate patient cohorts. Strikingly, unique lipidomic perturbation

SUBMITTER: Odenkirk MT 

PROVIDER: S-EPMC7824308 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature