MNBDR: A Module Network Based Method for Drug Repositioning.

ABSTRACT: Drug repurposing/repositioning, which aims to find novel indications for existing drugs, contributes to reducing the time and cost for drug development. For the recent decade, gene expression profiles of drug stimulating samples have been successfully used in drug repurposing. However, most of the existing methods neglect the gene modules and the interactions among the modules, although the cross-talks among pathways are common in drug response. It is essential to develop a method that utilizes the cross-talks information to predict the reliable candidate associations. In this study, we developed MNBDR (Module Network Based Drug Repositioning), a novel method that based on module network to screen drugs. It integrated protein-protein interactions and gene expression profile of human, to pr

SUBMITTER: Chen HG 

PROVIDER: S-EPMC7824496 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature