Insights into the Mechanism of Bovine Spermiogenesis Based on Comparative Transcriptomic Studies.

ABSTRACT: To reduce subfertility caused by low semen quality and provide theoretical guidance for the eradication of human male infertility, we sequenced the bovine transcriptomes of round, elongated spermatids and epididymal sperms. The differential analysis was carried out with the reference of the mouse transcriptome, and the homology trends of gene expression to the mouse were also analysed. First, to explore the physiological mechanism of spermiogenesis that profoundly affects semen quality, homological trends of differential genes were compared during spermiogenesis in dairy cattle and mice. Next, Gene Ontology (GO), Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment, protein-protein interaction network (PPI network), and bioinformatics analyses were performed to uncover the re

SUBMITTER: Li X 

PROVIDER: S-EPMC7824766 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature