Light chain deposition disease involving kidney and liver in a patient with IgD myeloma.

ABSTRACT:

Background

IgD multiple myeloma (MM) is a rare subtype of MM and light chain deposition disease (LCDD) outside the kidney is also a rare and has scarcely been reported. We report herein the details of the first reported case of LCDD involving the kidney and liver co-occurring with IgD myeloma.

Case presentation

A 66-year-old female with IgD MM presented with rapidly progressive acute renal failure, ascites and pleural effusion. Immunofluorescent study of revealed the characteristic linear deposition of Igκ light chain along the glomerular and tubular basement membrane in kidney. Electron microscopy showed the powdery electron-dense deposits along the tubular and glomerular basement membrane consistent with the diagnosis of LCDD. Laser microdissection followed by mass spectro

SUBMITTER: Tsushima T 

PROVIDER: S-EPMC7824927 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature