Malignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab.

ABSTRACT:

Background

Giant cell tumor of bone (GCTB) is a rare osteoclastogenic stromal tumor. GCTB can rarely undergo malignant transformation. This post hoc analysis evaluated and classified malignancies in patients with GCTB who received denosumab.

Methods

This analysis was conducted on patients with pathologically confirmed GCTB and measurable active disease treated with denosumab 120 mg subcutaneously once every 4 weeks, with loading doses on study days 8 and 15, as part of a phase 2, open-label, multicenter study. We identified potential cases of malignancy related to GCTB through an independent multidisciplinary review or medical history, associated imaging or histopathologic reports, and disease course. The findings were summarized and no statistical analysis was performed.

SUBMITTER: Palmerini E 

PROVIDER: S-EPMC7824947 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature