Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.

ABSTRACT:

Background

The regulatory roles of circular RNAs (circRNAs) in tumorigenesis have attracted increasing attention. However, novel circRNAs with the potential to be used as serum/plasma biomarkers and their regulatory mechanism in the pathogenesis of hepatocellular carcinoma (HCC) remain explored.

Methods

CircRNA expression profiles of tumor tissues and plasma samples from HCC patients were compiled and jointly analyzed. CircRNA-miRNA-mRNA interactions were predicted by bioinformatics tools. The expression of interacting miRNAs and mRNA was verified in independent datasets. Survival analysis and pathway enrichment analysis were conducted on hub genes.

Results

We identified three significantly up-regulated circRNAs (hsa_circ_0009910, hsa_circ_0049783, and hsa_circ_008917

SUBMITTER: Wang L 

PROVIDER: S-EPMC7824949 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature