Individual Variation in Functional Brain Network Topography is Linked to Schizophrenia Symptomatology.

ABSTRACT: Resting-state fMRI (rsfMRI) demonstrates that the brain is organized into distributed networks. Numerous studies have examined links between psychiatric symptomatology and network functional connectivity. Traditional rsfMRI analyses assume that the spatial organization of networks is invariant between individuals. This dogma has recently been overturned by the demonstration that networks show significant variation between individuals. We tested the hypothesis that previously observed relationships between schizophrenia-negative symptom severity and network connectivity are actually due to individual differences in network spatial organization. Forty-four participants diagnosed with schizophrenia underwent rsfMRI scans and clinical assessments. A multivariate pattern analysis determined how

SUBMITTER: Nawaz U 

PROVIDER: S-EPMC7824998 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature