Neurophysiological, Oculomotor, and Computational Modeling of Impaired Reading Ability in Schizophrenia.

ABSTRACT: Schizophrenia (Sz) is associated with deficits in fluent reading ability that compromise functional outcomes. Here, we utilize a combined eye-tracking, neurophysiological, and computational modeling approach to analyze underlying visual and oculomotor processes. Subjects included 26 Sz patients (SzP) and 26 healthy controls. Eye-tracking and electroencephalography data were acquired continuously during the reading of passages from the Gray Oral Reading Tests reading battery, permitting between-group evaluation of both oculomotor activity and fixation-related potentials (FRP). Schizophrenia patients showed a marked increase in time required per word (d = 1.3, P < .0001), reflecting both a moderate increase in fixation duration (d = .7, P = .026) and a large increase in the total saccade num

SUBMITTER: Dias EC 

PROVIDER: S-EPMC7825085 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature