Molecular subtypes based on DNA methylation predict prognosis in lung squamous cell carcinoma.

ABSTRACT:

Background

Due to tumor heterogeneity, the diagnosis, treatment, and prognosis of patients with lung squamous cell carcinoma (LUSC) are difficult. DNA methylation is an important regulator of gene expression, which may help the diagnosis and therapy of patients with LUSC.

Methods

In this study, we collected the clinical information of LUSC patients in the Cancer Genome Atlas (TCGA) database and the relevant methylated sequences of the University of California Santa Cruz (UCSC) database to construct methylated subtypes and performed prognostic analysis.

Results

Nine hundred sixty-five potential independent prognosis methylation sites were finally identified and the genes were identified. Based on consensus clustering analysis, seven subtypes were identified by using 96

SUBMITTER: Li XS 

PROVIDER: S-EPMC7825161 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature