Elucidation of the Genomic-Epigenomic Interaction Landscape of Aggressive Prostate Cancer.

ABSTRACT:

Background

Majority of prostate cancer (PCa) deaths are attributed to localized high-grade aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in clinical management of PCa is discovery and characterization of the molecular drivers of aggressive tumours. The development and progression of aggressive PCa involve genetic and epigenetic alterations occurring in the germline, somatic (tumour), and epigenomes. To date, interactions between genes containing germline, somatic, and epigenetic mutations in aggressive PCa have not been characterized. The objective of this investigation was to elucidate the genomic-epigenomic interaction landscape in aggressive PCa to identify potential drivers aggressive PCa and the pathways they control. We hypothesized th

SUBMITTER: Kumar Mamidi TK 

PROVIDER: S-EPMC7825361 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature