Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation.

ABSTRACT:

Aim

To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance.

Methods

Sixty-six African-Americans with LAP (7-21 years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin/metronidazole for 7 days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24 months following treatment. Levels of 16 inflammatory/bone resorption markers were determined using Milliplex^® . Univariate and correlation analyses were performed among all parameters/biomarkers. Discriminant analyses (DA) evaluated profile differences between LAP diseased

SUBMITTER: Branco-de-Almeida LS 

PROVIDER: S-EPMC7825363 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature