Kinetics of DNA Repair in Vicia faba Meristem Regeneration Following Replication Stress.

ABSTRACT: The astonishing survival abilities of Vicia faba, one the earliest domesticated plants, are associated, among other things, to the highly effective replication stress response system which ensures smooth cell division and proper preservation of genomic information. The most crucial pathway here seems to be the ataxia telangiectasia-mutated kinase (ATM)/ataxia telangiectasia and Rad3-related kinase (ATR)-dependent replication stress response mechanism, also present in humans. In this article, we attempted to take an in-depth look at the dynamics of regeneration from the effects of replication inhibition and cell cycle checkpoint overriding causing premature chromosome condensation (PCC) in terms of DNA damage repair and changes in replication dynamics. We were able to distinguish a unique b

SUBMITTER: Rybaczek D 

PROVIDER: S-EPMC7825715 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature