Deciphering the Role of Ca²⁺ Signalling in Cancer Metastasis: From the Bench to the Bedside.

ABSTRACT: Metastatic cancer is one of the major causes of cancer-related mortalities. Metastasis is a complex, multi-process phenomenon, and a hallmark of cancer. Calcium (Ca²⁺) is a ubiquitous secondary messenger, and it has become evident that Ca²⁺ signalling plays a vital role in cancer. Ca²⁺ homeostasis is dysregulated in physiological processes related to tumour metastasis and progression-including cellular adhesion, epithelial-mesenchymal transition, cell migration, motility, and invasion. In this review, we looked at the role of intracellular and extracellular Ca²⁺ signalling pathways in processes that contribute to metastasis at the local level and also their effects on cancer metastasis globally, as well as at underlying molecular mechanisms and c

SUBMITTER: Alharbi A 

PROVIDER: S-EPMC7825727 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature