Molecular docking analysis of rutin reveals possible inhibition of SARS-CoV-2 vital proteins.

ABSTRACT:

Background and aim

COVID-19 emerged by the end of 2019 in Wuhan, China. It spreaded and became a public health emergency all over the world by mid of April 2020. Flavonoids are specialized metabolites that have antimicrobial properties including anti-viral activity. Rutin, a medicinally important flavonoid belongs to one of the best natural antioxidant classes. It has antiprotozoal, antibacterial, and antiviral properties. Keeping the antimicrobial potential of rutin in mind, we studied its role in the inhibition of essential proteins of SARS-CoV-2 including main protease (M^pro), RNA-dependent RNA polymerase (RdRp), papain-like protease (PL^pro), and spike (S)-protein through different in silico approaches.

Experimental procedure

Molecular docking

SUBMITTER: Rahman F 

PROVIDER: S-EPMC7825826 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature