Repositioning of histamine H₁ receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2.

ABSTRACT: The spread of the corona virus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been intensifying in the past year, posing a huge threat to global health. There is an urgent need for effective drugs and vaccines to fight the COVID-19, but their advent may not be quite fast. Drug repurposing is a feasible strategy in the current situation, which could greatly shorten drug development time and help to response quickly to the novel virus outbreak. It has been reported that histamine H₁ receptor antagonists have broad-spectrum antiviral effects. Therefore, in this study, we aim to screen potential drugs among histamine H₁ receptor antagonists that may inhibit SARS-CoV-2 infection. Based on the model of angiotensin

SUBMITTER: Ge S 

PROVIDER: S-EPMC7826143 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature