STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case-Control Study.

ABSTRACT:

Introduction

Phosphorylation of signal transducer and activator of transcription 6 (STAT6) in the colonic epithelium is elevated in ulcerative colitis (UC) patients, and its inhibition prevents IL-13-associated apoptosis and barrier disruption. Recently, the STAT6 rs324015 polymorphism was reported to be related to genetic susceptibility to UC.

Methods

We examined STAT6 rs324015 using the PCR-RFLP method in 268 UC cases and 357 controls. STAT6 expression was determined by quantitative reverse-transcription PCR. The gene-environment interactions were addressed by cross-over analysis.

Results

We found that the STAT6 rs324015 polymorphism enhanced the risk of UC under the homozygous, dominant, and allelic models. Further subgroup analyses indi

SUBMITTER: Dai L 

PROVIDER: S-EPMC7826160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature