Colocality to Cofunctionality: Eukaryotic Gene Neighborhoods as a Resource for Function Discovery.

ABSTRACT: Diverging from the classic paradigm of random gene order in eukaryotes, gene proximity can be leveraged to systematically identify functionally related gene neighborhoods in eukaryotes, utilizing techniques pioneered in bacteria. Current methods of identifying gene neighborhoods typically rely on sequence similarity to characterized gene products. However, this approach is not robust for nonmodel organisms like algae, which are evolutionarily distant from well-characterized model organisms. Here, we utilize a comparative genomic approach to identify evolutionarily conserved proximal orthologous gene pairs conserved across at least two taxonomic classes of green algae. A total of 317 gene neighborhoods were identified. In some cases, gene proximity appears to have been conserved since befor

SUBMITTER: Foflonker F 

PROVIDER: S-EPMC7826186 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature