Computer-Aided Rapid Establishment of Fingerprint of Xiaojin Capsule by HPLC.

ABSTRACT: Traditional Chinese medicine (TCM) formulas have a significant clinical efficacy, and the fingerprint technology has been widely accepted to fully reveal the quality of TCM. Whereas, it is a great challenge to establish the fingerprint chromatogram which can fully reflect every single herb material in a short time. In this study, we used Xiaojin capsule (XJC) as a case and developed a rapid fingerprint method based on increasing the column temperature and flow rate simultaneously combined with computer-aided. First, the elution gradient was optimized based on the retention parameters and peak shape parameters of the four linear gradients, and then, the column temperature and flow rate were increased simultaneously to shorten the analysis time. Next, the standard fingerprint chromatogram of

SUBMITTER: Jiang H 

PROVIDER: S-EPMC7826213 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature