Exploration of the Immune-Related Signatures and Immune Infiltration Analysis in Melanoma.

ABSTRACT: In the present study, we aimed to investigate immune-related signatures and immune infiltration in melanoma. The transcriptome profiling and clinical data of melanoma were downloaded from The Cancer Genome Atlas database, and their matched normal samples were obtained from the Genotype-Tissue Expression database. After merging the genome expression data using Perl, the limma package was used for data normalization. We screened the differentially expressed genes (DEGs) and obtained immune signatures associated with melanoma by an immune-related signature list from the InnateDB database. Univariate Cox regression analysis was used to identify potential prognostic immune genes, and LASSO analysis was used to identify the hub genes. Next, based on the results of multivariate Cox regression ana

SUBMITTER: Li AL 

PROVIDER: S-EPMC7826228 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature