Ontology highlight
ABSTRACT:
SUBMITTER: Abel Y
PROVIDER: S-EPMC7826282 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20210101 2
The PAQosome is a large complex composed of the HSP90/R2TP chaperone and a prefoldin-like module. It promotes the biogenesis of cellular machineries but it is unclear how it discriminates closely related client proteins. Among the main PAQosome clients are C/D snoRNPs and in particular their core protein NOP58. Using NOP58 mutants and proteomic experiments, we identify different assembly intermediates and show that C12ORF45, which we rename NOPCHAP1, acts as a bridge between NOP58 and PAQosome. ...[more]