Systematic analysis of differential rhythmic liver gene expression mediated by the circadian clock and feeding rhythms.

ABSTRACT: The circadian clock and feeding rhythms are both important regulators of rhythmic gene expression in the liver. To further dissect the respective contributions of feeding and the clock, we analyzed differential rhythmicity of liver tissue samples across several conditions. We developed a statistical method tailored to compare rhythmic liver messenger RNA (mRNA) expression in mouse knockout models of multiple clock genes, as well as PARbZip output transcription factors (Hlf/Dbp/Tef). Mice were exposed to ad libitum or night-restricted feeding under regular light-dark cycles. During ad libitum feeding, genetic ablation of the core clock attenuated rhythmic-feeding patterns, which could be restored by the night-restricted feeding regimen. High-amplitude mRNA expression rh

SUBMITTER: Weger BD 

PROVIDER: S-EPMC7826335 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature