The natural axis of transmitter receptor distribution in the human cerebral cortex.

ABSTRACT: Transmitter receptors constitute a key component of the molecular machinery for intercellular communication in the brain. Recent efforts have mapped the density of diverse transmitter receptors across the human cerebral cortex with an unprecedented level of detail. Here, we distill these observations into key organizational principles. We demonstrate that receptor densities form a natural axis in the human cerebral cortex, reflecting decreases in differentiation at the level of laminar organization and a sensory-to-association axis at the functional level. Along this natural axis, key organizational principles are discerned: progressive molecular diversity (increase of the diversity of receptor density); excitation/inhibition (increase of the ratio of excitatory-to-inhibitory receptor dens

SUBMITTER: Goulas A 

PROVIDER: S-EPMC7826352 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature