Crucial role for CA2 inputs in the sequential organization of CA1 time cells supporting memory.

ABSTRACT: There is considerable evidence for hippocampal time cells that briefly activate in succession to represent the temporal structure of memories. Previous studies have shown that time cells can be disrupted while leaving place cells intact, indicating that spatial and temporal information can be coded in parallel. However, the circuits in which spatial and temporal information are coded have not been clearly identified. Here we investigated temporal and spatial coding by dorsal hippocampal CA1 (dCA1) neurons in mice trained on a classic spatial working-memory task. On each trial, the mice approached the same choice point on a maze but were trained to alternate between traversing one of two distinct spatial routes (spatial coding phase). In between trials, there was a 10-s mnemonic delay durin

SUBMITTER: MacDonald CJ 

PROVIDER: S-EPMC7826404 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature