Metabolic health is a determining factor for incident colorectal cancer in the obese population: A nationwide population-based cohort study.

ABSTRACT:

Background

The association of the risk of colorectal cancer (CRC) with obesity or obesity-induced metabolic disturbances remains controversial. We assessed the association of metabolic health status with incident CRC among subjects with obesity.

Methods

This study included 319,397 subjects from the Korean National Health Insurance Service-National Health Screening Cohort. Transitions in metabolic health status and obesity were examined during 2009-2010 and 2011-2012. We categorized subjects with obesity into four separate groups according to their dynamic metabolic health status: metabolically healthy obesity (MHO), MHO to metabolically unhealthy obesity (MUO), MUO to MHO, and stable MUO. Subjects were followed up from 2009 to 2015 for incident CRC.

Results

The stable

SUBMITTER: Cho YK 

PROVIDER: S-EPMC7826459 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature