Fatherhood status in relation to prostate cancer risks in two large U.S.-based prospective cohort studies.

ABSTRACT:

Background

Despite the high incidence and mortality of prostate cancer (PCa) in the Unites States, few risk factors have been consistently linked with these PCa outcomes. Assessing proxies of reproductive factors may offer insights into PCa pathogenesis. In this study, we examined fatherhood status as a proxy of fertility in relation to total, nonaggressive, aggressive, and fatal PCa.

Methods

We examined participants of two cohorts, the NIH-AARP Diet and Health (NIH-AARP) Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. We used Cox proportional hazards regression to estimate hazard ratios (HRs) and 95% confidence intervals of associations between fatherhood status and number of children sired in relation to PCa incidence.

Results

Father

SUBMITTER: Geczik AM 

PROVIDER: S-EPMC7826462 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature