Lidocaine inhibits the metastatic potential of ovarian cancer by blocking Na_V 1.5-mediated EMT and FAK/Paxillin signaling pathway.

ABSTRACT: Lidocaine, one of the most commonly used local anesthetics during surgery, has been reported to suppress cancer cell growth via blocking voltage-gated sodium channels (VGSCs). VGSC 1.5 (Na_V 1.5) is highly expressed in invasive cancers including ovarian cancer. This study aims to investigate whether lidocaine inhibits the malignancy of ovarian cancer through Na_V 1.5 blockage. Human ovarian cancer, its metastatic cancer and normal ovarian tissues were probed with anti-Na_V 1.5 antibody in situ. Human ovarian cancer A2780 and SKOV3 cells were cultured and their growth, epithelial-mesenchymal transition (EMT), migration, and invasion in the presence or absence of lidocaine together with underlying molecular mechanisms were assessed. Murine syngeneic ovarian canc

SUBMITTER: Liu C 

PROVIDER: S-EPMC7826465 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature