Perioperative CRP: A novel inflammation-based classification in gastric cancer for recurrence and chemotherapy benefit.

ABSTRACT:

Background

Perioperative C-reactive protein (CRP) levels have effects on the prognosis of cancer patients. We intended to determine the prognostic value of combining the two for gastric cancer (GC).

Methods

Data were extracted from a clinical trial. By calculating the area under the curve (AUC) and the C-index, the predictive value of CRPs among different time points, including preoperative (pre-CRP), postoperative days 1, 3, and 5 (post-CRPs), and postoperative maximum CRP (post-CRP_max ), was derived. Multivariate analysis was performed to further explore the independent variates for recurrence-free survival (RFS).

Results

Finally, 401 patients were available in the present study. For RFS, higher AUC (0.692) and concordance index (0.678) of pre-CRP were ob

SUBMITTER: Lu J 

PROVIDER: S-EPMC7826470 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature