Clinical characteristics and management of immune checkpoint inhibitor-related pneumonitis: A single-institution retrospective study.

ABSTRACT:

Introduction

The increasing application of immune checkpoint inhibitors (ICIs) will cause more checkpoint inhibitor-related pneumonitis (CIP), which is a common cause of ICI-related death. The clinical management of CIP needs further optimization.

Methods

Patients who were managed at Peking Union Medical College Hospital (PUMCH) between February 2017 and December 2019 with a diagnosis of CIP were retrospectively analyzed. Clinical data including clinical manifestations, radiologic data, laboratory and bronchoscopy results, treatments, and outcomes were collected and analyzed. The Mann-Whitney test was used to compare patients with and without co-infections.

Results

In total, 48 CIP cases in 42 patients were analyzed. The median time from the first dose of ICI to the o

SUBMITTER: Wang H 

PROVIDER: S-EPMC7826478 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature