N6-methyladenine-related genes affect biological behavior and the prognosis of glioma.

ABSTRACT:

Background

Although aberrant expression of N6-methyladenine (m⁶ A) methylation-related genes contribute to tumorigenesis in many solid tumors, the prognostic value of the m⁶ A-related genes and their correlation with clinicopathological features in gliomas need advanced study.

Methods

The clinical and sequencing data of 288 patients with glioma were extracted from Chinese Glioma Genome Atlas database. By univariate and multivariable Cox regression analysis, the m⁶ A-related prognostic genes were identified, and their correlation with clinicopathological features was further analysis. A nomogram was constructed by R software and the performance of it was assessed by calibration and time-dependent receiver operating characteristic curve.

Res

SUBMITTER: Qu S 

PROVIDER: S-EPMC7826482 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature