Epigenetic Modifications Induced by Olive Oil and Its Phenolic Compounds: A Systematic Review.

ABSTRACT: Many studies demonstrated that olive oil (especially extra virgin olive oil: EVOO) phenolic compounds are bioactive molecules with anti-cancer, anti-inflammatory, anti-aging and neuroprotective activities. These effects have been recently attributed to the ability of these compounds to induce epigenetics modifications such as miRNAs expression, DNA methylation and histone modifications. In this study, we systematically review and discuss, following the PRISMA statements, the epigenetic modifications induced by EVOO and its phenols in different experimental systems. At the end of literature search through "PubMed", "Web of Science" and "Scopus", 43 studies were selected.Among them, 22 studies reported data on miRNAs, 15 on DNA methylation and 13 on histone modification. Most of the "epigeno

SUBMITTER: Fabiani R 

PROVIDER: S-EPMC7826507 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature