Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation.

ABSTRACT: Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein-protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence. This promiscuity allows for one AR domain to recognize and bind to a variety of intracellular substrates, suggesting that AR-containing proteins may be involved in a wide array of functions. Many AR-containing proteins serve a critical role in biological processes including the ubiquitylation signaling pathway (USP). There is also strong evidence that AR-containing protein malfunction are associated with several neurological diseases and disorders. In this review, the structu

SUBMITTER: Kane EI 

PROVIDER: S-EPMC7826745 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature