Interactions of Potential Anti-COVID-19 Compounds with Multispecific ABC and OATP Drug Transporters.

ABSTRACT: During the COVID-19 pandemic, several repurposed drugs have been proposed to alleviate the major health effects of the disease. These drugs are often applied with analgesics or non-steroid anti-inflammatory compounds, and co-morbid patients may also be treated with anticancer, cholesterol-lowering, or antidiabetic agents. Since drug ADME-tox properties may be significantly affected by multispecific transporters, in this study, we examined the interactions of the repurposed drugs with the key human multidrug transporters present in the major tissue barriers and strongly affecting the pharmacokinetics. Our in vitro studies, using a variety of model systems, explored the interactions of the antimalarial agents chloroquine and hydroxychloroquine; the antihelmintic ivermectin; and the proposed

SUBMITTER: Telbisz A 

PROVIDER: S-EPMC7827085 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature