Candida parapsilosis Colony Morphotype Forecasts Biofilm Formation of Clinical Isolates.

ABSTRACT: Candida parapsilosis is a frequent cause of fungal bloodstream infections, especially in critically ill neonates or immunocompromised patients. Due to the formation of biofilms, the use of indwelling catheters and other medical devices increases the risk of infection and complicates treatment, as cells embedded in biofilms display reduced drug susceptibility. Therefore, biofilm formation may be a significant clinical parameter, guiding downstream therapeutic choices. Here, we phenotypically characterized 120 selected isolates out of a prospective collection of 215 clinical C. parapsilosis isolates, determining biofilm formation, major emerging colony morphotype, and antifungal drug susceptibility of the isolates and their biofilms. In our isolate set, increased biofilm formation capacity w

SUBMITTER: Gomez-Molero E 

PROVIDER: S-EPMC7827155 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature