Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes.
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ABSTRACT:
SUBMITTER: Choi JH
PROVIDER: S-EPMC7827407 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes.
Choi Jae Ho JH Jin Sun Woo SW Lee Gi Ho GH Han Eun Hee EH Hwang Yong Pil YP Jeong Hye Gwang HG
Antioxidants (Basel, Switzerland) 20210110 1
Rutaecarpine, an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of <i>Evodia</i> <i>rutaecarpa</i>, is used to treat hypertension, postpartum hemorrhage, dysentery, and amenorrhea as a traditional medicine in Asia. We investigated the effect of rutaecarpine on acetaminophen-induced hepatotoxicity in mice. Rutaecarpine was administered orally daily for seven consecutive days, followed by intraperitoneal injection of acetaminophen in mice on day seven to induce hepatotoxicity. R ...[more]
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