Genetic Variations in Prostaglandin E₂ Pathway Identified as Susceptibility Biomarkers for Gastric Cancer in an Intermediate Risk European Country.

ABSTRACT: The cyclooxygenase-2 (COX-2)/prostaglandin E₂ (PGE₂) pathway exerts deleterious pleiotropic effects in inflammation-induced gastric carcinogenesis. We aimed to assess the association of genetic variants in prostaglandin-endoperoxide synthase 2 (PTGS2), ATP binding cassette subfamily C member 4 (ABCC4), hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), and solute carrier organic anion transporter family member 2A1 (SLCO2A1) PGE₂ pathway-related genes with gastric cancer (GC) risk in a European Caucasian population. A hospital-based case-control study gathering 260 GC cases and 476 cancer-free controls was implemented. Using a tagSNP approach, 51 single nucleotide polymorphisms (SNPs) were genotyped through MassARRAY^®

SUBMITTER: Lopes C 

PROVIDER: S-EPMC7827533 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature