Pregnant Women Infected with Zika Virus Show Higher Viral Load and Immunoregulatory Cytokines Profile with CXCL10 Increase.

ABSTRACT: Zika virus (ZIKV) infection during pregnancy usually shows only mild symptoms and is frequently subclinical. However, it can be vertically transmitted to the fetus, causing microcephaly and other congenital defects. During pregnancy, the immune environment modifications can alter the response to viruses in general and ZIKV in particular. To describe the role of pregnancy in the systemic pro- and anti-inflammatory response during symptomatic ZIKV infection. A multiplex assay was used to measure 25 cytokines, chemokines, and receptors in 110 serum samples from pregnant and nonpregnant women with and without ZIKV infection with and without symptoms. Samples were collected through an epidemiological surveillance system. Samples from pregnant women with ZIKV infection showed a higher viral load

SUBMITTER: Camacho-Zavala E 

PROVIDER: S-EPMC7827657 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature