Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System.

ABSTRACT: Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of disease states. Consequently, the discovery and development of systems suitable for the detection of hypoxanthine is pretty appealing in this research field. Thus, we have obtained a stable diruthenium (III) compound in its dehydrated and hydrated forms with formula [{Ru(µ-Cl)(µ-hpx)}₂Cl₄] (1a) and [{Ru(µ-Cl)(µ-hpx)}₂Cl₄]·2H₂O (1b), respectively. This purine-based diruthenium(III) system was prepared from two very different starting materials, namely, inosine and azathioprine, t

SUBMITTER: Orts-Arroyo M 

PROVIDER: S-EPMC7827764 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature